The Consumers Guide to Biologics for Psoriasis

Psoriasis appears to be a skin condition, but plaques and other symptoms are brought on by internal inflammation. The best way to treat moderate to severe cases of the skin condition is frequently with systemic drugs that suppress the immune system's inflammatory response.

Your body produces this inflammation for what reason? It is a natural immune system that safeguards against invading pathogens that could make you ill. In contrast, when you have skin problems, your immune system is overactive, which results in excessive inflammation and excessive skin cell growth, which results in plaques on your skin.

Psoriasis is, in other words, an autoimmune disorder in which your immune system becomes "mad" at your skin.

How do Biologics help in Curing Skin Problems?

Using living cells that resemble chemicals in your immune system, biologics are manufactured. They operate inside the body to combat plaques of psoriasis and inflammation where they originate.

Two factors set biologics apart from other popular psoriasis treatments −

  • By stopping the inflammatory process in your body before it even begins, biologics target the underlying cause of the skin ailment rather than just the existing plaques (as do topical medications).

  • Biologics target particular molecules associated with this skin disorder compared to conventional systemic medications, which generally inhibit the immune system.

How are Biologics Used?

Depending on the biologics type, this changes. Either an injection or an infusion is given through an IV. Some shots are ones you can administer to yourself at home after you learn how. You must visit your doctor's office or an infusion facility to receive infliximab treatment because it requires an infusion (via an IV).

The biologic has to be consumed once every three months or twice weekly. How frequently you should take it will be determined by your dermatologist.

The light treatment uses artificial or natural ultraviolet light to lessen inflammation and limit the proliferation of skin cells. UVA or UVB light generated artificially or naturally are both used in phototherapy.

To reduce inflammation and stop the symptoms and progression of the skin condition, medications like methotrexate and cyclosporine broadly weaken the immune system. They are used as a standalone treatment for this skin problem or in conjunction with a biologic.

Your preferences and the severity of your psoriasis will determine how you are treated. Topical treatments may be effective in moderate cases, but systemic drugs, such as biologics, may be required if larger body surfaces are affected.

What are the Benefits of Using Biologics for Treating this skin Problem?

An important therapeutic option for those with moderate-to-severe psoriasis is a biologic. When other therapies failed to regulate their symptoms, taking a biologic changed the course of many people's lives by controlling their symptoms.

Biologics function by preventing the bodily processes that lead to psoriasis and its symptoms.

Safety and Effectiveness of Biologics in Curing Psoriasis

Generally, biologics have an excellent track record for safety.

The greatest worry is still the possibility that a patient will get a dangerous infection. Because of this, dermatologists thoroughly examine every patient before recommending a biologic.

Before deciding whether to prescribe a biologic to treat your psoriasis, your dermatologist will perform a few medical tests on you. In most cases, blood tests and TB testing are necessary. Some patients require further diagnostic procedures.

Research demonstrates the potential effectiveness of the biologics licensed to treat this skin condition. A biologic may provide the most effective therapy option for many individuals with moderate-to-severe skin disease.

A biologic usually works better if you take it regularly. A biologic may lose its efficacy and experience some negative effects if it is stopped and started again.

Moreover, a biologic may stop working after being taken for a while. If this occurs, another biologic might be effective.

A biologic can become less effective with time, but studies demonstrate that for many patients, a biologic is a long-lasting and safe treatment.

What are the Side Effects of Biologics?

The list of potential side effects for each biologic is different. The majority of them are minor and do not lead to patients stopping their biologic therapy. Biologics have some side effects like −

  • Infection of the upper respiratory tract

  • The injection site causes a skin problem

  • Flu-like signs

  • Infections of the urinary tract

  • Headache

Anyone using a biologic has a higher chance of getting a grave infection since biologics function by calming down a portion of your immune system. Those who have diabetes, smoke or chew tobacco, or have a history of infections are at a higher risk. Those who are older also have a larger risk.

Can one take Vaccines when Taking a Biologic?

Call your dermatologist before receiving a flu shot or any other vaccination. Getting some vaccines while taking a biologic is not advisable.

When must one Consider Trying Biologics for Treating this skin Disorder?

  • For better effectiveness, many psoriasis techniques need to be taken every day. Whether you're busy or frequently on the go, it might be challenging to remember to take your prescription on schedule. Contrarily, biologics are often taken less regularly. Some biologics require weekly injections, whereas others require only one injection every 12 weeks following the initial two doses. Most biologics can also be administered by you at home after receiving training from a medical practitioner.

  • The side effects of psoriasis medications like cyclosporine, corticosteroids, and methotrexate include mouth sores, nausea, upset stomach, and skin cancer. Compared to other psoriasis therapies, biologics function more selectively. They target particular immune system proteins that have been linked to this skin condition in studies. They have fewer adverse effects as a result than less focused treatments.

  • If your psoriasis hampers your quality of life, biologics may be appropriate for you. Typically, they are only prescribed for people with moderate to severe psoriasis. Even if your skin ailment is considered minor, you could still have uncomfortable plaques on the palms of your hands, face, or genitalia. You might be unable to perform your daily tasks due to the pain. A move to a biologic may be appropriate in certain circumstances.

  • When traditional treatments are not working, one can consider using Biologics.


It is crucial to understand that not every biologic is effective for everyone. One biologic might not be able to help you, but another might. Consult with your doctor to understand which one suits your condition the best.

Updated on: 30-Mar-2023


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