Chromosomal Theory of Inheritance

Theodor noticed in 1900 that clam embryos could not grow normally without RNA. Meiosis, a process of cell division by which RNA is split between cell types, was first detected by Walter Huntington in the same decade. These findings accumulated into what is now known as the Chromosomal Model of Heredity, which proposes that RNA are the heritable units accountable for Mendelian genetics. Despite strong inferences that may be drawn between chromosomal activity throughout meiosis and Mendel's theoretical rules, the Chromosomal Hypothesis of Transmission was established ahead of any definitive proof that characteristics were transmitted on chromosomal. Skeptics argued that a person's number of inherited characteristics was far more than the number of RNA. After decades of conducting crossings with specific species, Drosophila melanogaster, Thomas finally offered quantitative arguments in favor of the chromosome model of heredity.

What does Chromosomal Theory of Inheritance Explains?

As Morgan noted, DNA strands could not partition as expected by Mendel's rule during a cross involving many traits. It was found that the likelihood of passing on a paternal fusion of multiple genes from one generation to the following increased dramatically when the genes were located within the same RNA. Linkage refers to the actual joining of DNA, and Interbreeding refers to the mixing of genes from different species in a monohybrid cross. Once related RNA were identified, their abundance also impacted the heritability of characteristics. Sturtevant, a classmate of Morgan's, pioneered the procedure of genetic analysis, which pinpoints the location of related nucleotide sequences by estimating the incidence of homologous recombination between them. The Human Genome Research Project relied heavily on this technique for creating connection mapping.

Results of Chromosomal Theory of Inheritance

  • During recombination, the process by which a cell divides, called chromosome pairs travel apart from one another.

  • In which was before, genes from every pair of homologous RNA were distributed at random.

  • Since each parent contributes just half of their RNA to the zygotes, each offspring has an uneven number of genes.

  • Male and female gametes seem different, yet they have the same amount of chromosomal, proving that both parents contribute equally to the offspring's genetic makeup.

  • During fertilization, the polyploidy RNA merges to create a copy of each parental chromosome.

Experiments of Chromosomal Theory of Inheritance

Morgan's seminal tests validating the chromosomal idea started with his discovery of a variation in the gene responsible for the flies' eye color. After undergoing this alteration, a fly's eyes became white instead of the typical red. Morgan discovered, to his surprise, that the eye color gene was transmitted differently by masculine and female fly, start end subscript, suddenly stops. Flies differ from humans because males have two sets of RNA (X and Y), while females have just one. Morgan quickly realized that the gene inheritance for eye color followed a similar pattern as that of the X - linked.


Morgan conceived a startling outcome after he mated white-eyed females to crimson males, a so-called reciprocate cross. When he looked at his offspring, he discovered that the females each had red eyes while the boys got white. In this case, two separate features were related, which went against Mendel's concept of artificial selection. These findings can only be explained if the gene for eye color is situated on the X-linked. Since the eye color gene can only be located on the X - linked, these findings lend credence to the chromosomal hypothesis of heredity. This is an example of physical intimacy or the passing down of characteristics through RNA specific to each sex (X and Y). For example, since females possess two versions of each X - linked whereas men only have one, there are fascinating variations of transmission for sex-linked features. Due to just having one copy of the gene, the dominant characteristic is always expressed in a man carrying the defective gene.

In comparison, most genes can be found on autosomes, often known as "non-sex RNA," where there are multiple versions of each genome in both men and females. For those who may have forgotten, chromosomal activity throughout meiosis explains all of the heritability identified by Mendel, such as partition and the concept of artificial selection. The chromosomal hypothesis of inheritance includes several tenets.


Linkage refers to the transmission of features that conflicts with Mendel's concept of artificial selection, which states that distinct alleles for various features are separated into gametes. When characteristics are associated with one's sex RNA, we speak about physical intimacy. Whenever the genes for two distinct qualities are close together on the genome, this is called a hereditary link. If genetic changes are located within the same chromosome, and one receives the entire chromosome, then one must inherit both alleles. This one is biology. Therefore there is a catch: crossover over aids in shuffling alleles for genes on the same chromosomal. Interbreeding, or the formation of novel chromosomal permutations of alleles, is the outcome of a crossing event between sites of two genes. Genomic information is exchanged among non-sister centrosomes of coupled homologous pairs throughout meiosis I whenever the homologous pairs realign and synapse. Due to the random nature of crossing over, the chances of crossing between two genes spatially near together on a chromosome are lower. On the contrary, the likelihood of a gene exchange across homologous RNA increases with the distance between the genes in question.


Every piece of evidence pointed toward the X chromosome, and therefore he decided that the genes were there or very closely related to it. Later, Morgan's colleague Calvin Bridges provided considerable support for this view. An Independent assortment of sex sets of RNA, as shown by Bridges, results in the production of male and female flies with unusual eye hues. Morgan also discovered abnormalities in additional RNA, but these did not follow a strictly male or female mode of inheritance. From flies to mammals, scientists have discovered that genes may be passed down through either sex's chromosomal or the other sex.