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Difference Between Genome Sequencing and Genome Mapping
Genome sequence and genome map are both engravings of a genome.
Genome mapping is useful for pinpointing the location of and determining the proximity of individual genes. The Human Genome Project (HGP) is a worldwide scientific endeavour that can make use of this technique as a foundational first step. Low-resolution and high-resolution physical mapping, restriction enzymes as microscopic scalpels, genetic linkage maps, macro-restriction maps as a top-down approach, and contig maps as a bottom-up approach are all examples of mapping methods. Chromosome Isolation (Flow Sorting and Somatic Cell Hybridization)
Genome sequencing is a technique for evaluating the whole deoxyribonucleic acid sequence of a cell or organism in a single experiment. Whole-genome sequencing is another phrase for genomic analysis. Whole genome shotgun sequencing and the clone-by-clone technique are two sequencing approaches (does not require a genome map).
There is an effort to employ this technique as a research tool to aid in the development of therapeutic or pharmacological therapies.
What is Genome Sequencing?
Evaluation of the nucleic acid sequence, or the order of nucleotides (the fundamental building unit of nucleic acids) in DNA, is accomplished by a process known as genome sequencing. Adenine (A), Guanine (G), Cytosine (C), and Thymine (T) are the four nitrogenous biological components that make up DNA (T)
What is Genome Mapping?
It's a map of the human genome's internal structure. A genetic map is a useful tool for locating markers along the chromosomes (a lengthy molecule of Deoxyribonucleic acid containing a portion or the full genome of an organism).
Similarities: Genome Sequencing and Genome Mapping
Both are methods for analyzing genomes
Both are used to figure out the location of the genes
Also, both processes help in assessing illness/disease causing genes in the genome.
Differences: Genome Sequencing and Genome Mapping
The following table highlights the major differences between Genome Sequencing and Genome Mapping −
Characteristics |
Genome Sequencing |
Genome Mapping |
|---|---|---|
Definition |
DNA and RNA are composed of organic molecules called nucleotides, and gene sequencing requires determining the precise sequence of these building blocks. The information provided by gene sequencing is more exhaustive and detailed than any previously available. |
Generating a chromosomal blueprint, or "genome map," involves identifying and placing DNA sequences on chromosomes. |
Methods |
|
|
Advantages |
|
|
Time and Cost |
This is a very pricey method and is also time-consuming |
Genome mapping is not expensive and is a cheap method. It also takes very less time. |
Conclusion
In conclusion, gene sequencing offers complete and comprehensive details, while gene mapping offers lesser details.
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